Browsing by Author "Liu, Zijuan"

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    Current Perspectives on Autism Spectrum Disorder: Causes, Diagnosis, and Treatment
    Lillemoen, Faith; Liu, Zijuan
    Autism spectrum disorder (also called ASD) is a pervasive disorder that strongly impacts the lives of affected individuals and their families. While the incidence of the disease has been increasing, little is understood about the exact mechanisms behind the disorder or how to treat it. Research must continue to determine the genetic and environmental factors that contribute to ASD. The methods of diagnosing ASD must also be scrutinized. Developments in these areas could greatly impact the lives of people who have ASD. Knowledge of the underlying mechanisms could provide the key to biological treatment, while more specific diagnoses could allow for greater distinction between individuals on the spectrum based on their personal abilities and needs. Additionally, research into pharmacologic, therapeutic, and non-invasive treatments could improve the quality of life for individuals who have ASD. The present paper seeks to synthesize current research on the causes, diagnosis, and treatment of autism spectrum disorder, then propose directions for future research. Through a detailed examination of the current literature, new directions will be determined.
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    Detecting Behavioral Changes in an Autism Mouse Model after Treatment with Ergothioneine
    (2024-12-10) Carpenter, Morgan R.; Pillivant, Dylan; Liu, Zijuan; Stamatovski, Daniel
    Autism Spectrum Disorder (ASD) is a neurological disorder that can impair developmental, behavioral, and social skills. Although there are currently no curative remedies authorized for the treatment of autism spectrum disorder, certain dietary supplements may act as a form of therapy for some of the atypical behaviors associated with this diagnosis. Ergothioneine (ET) is an amino acid derivative known for its antioxidant properties and its ability to enhance neurological function. Here we utilized ET supplementation to examine the potential benefits it may have on autism phenotypes. A BTBR autistic mouse model was used to test the effects of ET treatment followed by behavioral examination. Quantitative analyses of behavioral changes observed between the treatment group along with controls were performed to determine if ET could improve autism-like behaviors. The long-term goal of this study is to establish the possible application of a safe ET supplementation to ameliorate autistic manifestations in ASD children.