Detecting Behavioral Changes in an Autism Mouse Model after Treatment with Ergothioneine

Autism Spectrum Disorder (ASD) is a neurological disorder that can impair developmental, behavioral, and social skills. Although there are currently no curative remedies authorized for the treatment of autism spectrum disorder, certain dietary supplements may act as a form of therapy for some of the atypical behaviors associated with this diagnosis. Ergothioneine (ET) is an amino acid derivative known for its antioxidant properties and its ability to enhance neurological function. Here we utilized ET supplementation to examine the potential benefits it may have on autism phenotypes. A BTBR autistic mouse model was used to test the effects of ET treatment followed by behavioral examination. Quantitative analyses of behavioral changes observed between the treatment group along with controls were performed to determine if ET could improve autism-like behaviors. The long-term goal of this study is to establish the possible application of a safe ET supplementation to ameliorate autistic manifestations in ASD children.