The Delineation of the Fibrinogen/Triggering Receptor in Myeloid Cells (TREM) Like Transcript - (TLT) -1 Molecular Interaction

dc.contributor.advisor	Washington, Anthony V
dc.contributor.author	Branfield, Siobhan Laken
dc.contributor.other	Bonney, Elizabeth A
dc.contributor.other	Hosch, Sarah
dc.contributor.other	Westrick, Randal J
dc.date.accessioned	2024-10-11T18:04:39Z
dc.date.available	2024-10-11T18:04:39Z
dc.date.issued	2024-01-01
dc.description.abstract	Triggering Receptor Expressed in Myeloid Cells -1 (TLT- 1) is a platelet specific receptor that facilitates platelet aggregation and plays a role in immunohemostasis. Previous studies identified fibrinogen as a ligand for TLT-1 but little has been reported on the molecular interaction or the role this TLT-1/Fibrinogen interaction has on pathophysiological progression of disease. This dissertation research presents basic research, with potential for translational application for this interaction, highlighting the versatile functionalization and application of TLT-1 as a contributor to clot formation, as a biomarker for disease progression and, extends to understand its regulation of fibrinogen deposition in pathophysiological models of disease.
dc.identifier.uri	https://hdl.handle.net/10323/18321
dc.relation.department	Biomedical Sciences
dc.subject	Fibrinogen
dc.subject	Hemostasis
dc.subject	Platelets
dc.subject	Thromboinflammation
dc.subject	Thrombosis
dc.subject	Trem Like Transcript-1
dc.title	The Delineation of the Fibrinogen/Triggering Receptor in Myeloid Cells (TREM) Like Transcript - (TLT) -1 Molecular Interaction

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