The Delineation of the Fibrinogen/Triggering Receptor in Myeloid Cells (TREM) Like Transcript - (TLT) -1 Molecular Interaction

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dc.contributor.advisorWashington, Anthony V
dc.contributor.authorBranfield, Siobhan Laken
dc.contributor.otherBonney, Elizabeth A
dc.contributor.otherHosch, Sarah
dc.contributor.otherWestrick, Randal J
dc.date.accessioned2024-10-11T18:04:39Z
dc.date.available2024-10-11T18:04:39Z
dc.date.issued2024-01-01
dc.description.abstractTriggering Receptor Expressed in Myeloid Cells -1 (TLT- 1) is a platelet specific receptor that facilitates platelet aggregation and plays a role in immunohemostasis. Previous studies identified fibrinogen as a ligand for TLT-1 but little has been reported on the molecular interaction or the role this TLT-1/Fibrinogen interaction has on pathophysiological progression of disease. This dissertation research presents basic research, with potential for translational application for this interaction, highlighting the versatile functionalization and application of TLT-1 as a contributor to clot formation, as a biomarker for disease progression and, extends to understand its regulation of fibrinogen deposition in pathophysiological models of disease.
dc.identifier.urihttps://hdl.handle.net/10323/18321
dc.relation.departmentBiomedical Sciences
dc.subjectFibrinogen
dc.subjectHemostasis
dc.subjectPlatelets
dc.subjectThromboinflammation
dc.subjectThrombosis
dc.subjectTrem Like Transcript-1
dc.titleThe Delineation of the Fibrinogen/Triggering Receptor in Myeloid Cells (TREM) Like Transcript - (TLT) -1 Molecular Interaction

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