The Delineation of the Fibrinogen/Triggering Receptor in Myeloid Cells (TREM) Like Transcript - (TLT) -1 Molecular Interaction

Abstract

Triggering Receptor Expressed in Myeloid Cells -1 (TLT- 1) is a platelet specific receptor that facilitates platelet aggregation and plays a role in immunohemostasis. Previous studies identified fibrinogen as a ligand for TLT-1 but little has been reported on the molecular interaction or the role this TLT-1/Fibrinogen interaction has on pathophysiological progression of disease. This dissertation research presents basic research, with potential for translational application for this interaction, highlighting the versatile functionalization and application of TLT-1 as a contributor to clot formation, as a biomarker for disease progression and, extends to understand its regulation of fibrinogen deposition in pathophysiological models of disease.