Benzodiazepine Coordination Chemistry And Nitrogen Heterocyclic Compounds From Reactions Of Carbonyl Alkynes With O-Phenylenediamines

Simple item page
dc.contributor.advisorDembinski, Roman
dc.contributor.authorTwardy, Dylan Joseph
dc.contributor.otherBeyeh, Ngong
dc.contributor.otherChavez, Ferman
dc.contributor.otherWheeler, Kraig
dc.contributor.otherYang, Ziming
dc.date.accessioned2022-11-15T17:43:17Z
dc.date.available2022-11-15T17:43:17Z
dc.date.issued2022-07-19
dc.description.abstractThe presence of heterocyclic compounds in active pharmaceutical ingredients and natural products implicates their importance to synthetic chemistry. Moreover, their inherent structures offer potential as metal-chelators. This work involved the design of simple methods for the construction of new nitrogen-containing heterocycles and to explore examples of coordination complexes. Benzodiazepines and their derivatives are biologically active heterocycles often prescribed as a treatment for anxiety, epilepsy, and insomnia. In addition, benzimidazo[2,1-a]isoquinolines are another class of biologically active heterocycles that are composed of moieties inherent to a wide variety of active pharmaceutical ingredients. Herein, the microwave-assisted reaction in ethanol of o-phenylenediamines with either alk-2-ynones or 2-ethynyl benzaldehydes was found to yield 1,5-benzodiazepines and benzimidazo[2,1-a]isoquinolines, respectively. To facilitate selective coordination of benzodiazepines, new pyridine containing 1,5-benzodiazepine chelators were synthesized and combined with metal reagents to form new benzodiazepine metal complexes characterized by X-ray crystallography.
dc.identifier.urihttp://hdl.handle.net/10323/12005
dc.relation.departmentChemistry
dc.subjectOrganic chemistry
dc.subjectBenzodiazepines
dc.subjectBiomedical sciences
dc.subjectHeterocycles
dc.titleBenzodiazepine Coordination Chemistry And Nitrogen Heterocyclic Compounds From Reactions Of Carbonyl Alkynes With O-Phenylenediamines
dc.typeDissertation

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Benzodiazepine_Coordination_Ch.pdf
Size:
3.23 MB
Format:
Adobe Portable Document Format
Description:
Dissertation
Download

Collections

Chemistry