Browsing by Author "Sevilla, Michael"

Now showing 1 - 3 of 3
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    Comment on Author Barbara Oakley’s New Book, Evil Genes
    (Oakland University, 2008-01-01) Sevilla, Michael; Murphy, Brian; Nixon, Jude V.
    Two reviews of Barbara Oakley's book "Evil Genes".
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    Discrete Functionalization of Resorcinarenes for Applications in Supramolecular Chemistry
    (2023-01-01) Twum, Kwaku; Beyeh, Ngong K.; Sevilla, Michael; Yang, Ziming; Madlambayan, Gerard
    Resorcinarenes are three-dimensional cyclic oligomers obtained by acid-catalyzed condensation between resorcinol and an appropriate aldehyde. This doctoral thesis research presents basic and translational research studies that demonstrate the versatile functionalization and applications of the resorcinarene macrocycle. In chapter one, this thesis introduces macrocyclic chemistry with a brief reflection on the history of the science and Beyeh Lab’s use of the resorcinarene macrocycle in supramolecular chemistry. Chapter two presents a fundamental study of cooperativity in non-covalent interactions using a resorcinarene as an anchor to a guest in a solution that restricts its free rotation in the solution. Chapter three explores the molecular recognition potential of functionalized resorcinarenes as sensors for ammonium cations and pyrophosphate anions. Last, chapter four presents functionalized water-soluble resorcinarenes as aggregation inhibitors for peptides that cause eye cataracts. These applications are all realized through the persistent hydrophobic cavity inherent in the basic resorcinarene cavitand and the synthetic functionalization of the macrocyclic ring, which underscores the versatile use of resorcinarene compounds in supramolecular chemistry.
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    Investigation of Reactions of Radiation-Produced Electrons with Azido-Nucleosides: Formation and Identification of Radical Intermediates
    Barbolovici, Alexandru; Sevilla, Michael; Adhikary, Amitava
    This project elucidates the mechanisms involved in the formation of site-specific pi-type neutral aminyl radicals (pi-RNH•) via the reaction of radiation-produced electrons with certain azido-DNA model systems including azidonucleosides in the absence of oxygen. Subsequent reactions of these oxidizing pi-RNH• that were produced reductively, were investigated. Experimental investigations on formation of these pi-RNH• and their subsequent reactions were carried out using Electron Spin Resonance (ESR) spectroscopy. The hyperfine coupling constant (HFCC) values were calculated employing Density Functional Theory (DFT). Combination of ESR spectral studies and DFT calculations led to radical assignments and interpretations of ESR spectra. Reactions of these pi-RNH• would reveal whether these azido-DNA model systems can be applied as potential radiosensitizers (compounds which augment radiation damage), used for radio-chemotherapy of tumors.