Washington, Anthony VBranfield, Siobhan LakenBonney, Elizabeth AHosch, SarahWestrick, Randal J2024-10-112024-10-112024-01-01https://hdl.handle.net/10323/18321Triggering Receptor Expressed in Myeloid Cells -1 (TLT- 1) is a platelet specific receptor that facilitates platelet aggregation and plays a role in immunohemostasis. Previous studies identified fibrinogen as a ligand for TLT-1 but little has been reported on the molecular interaction or the role this TLT-1/Fibrinogen interaction has on pathophysiological progression of disease. This dissertation research presents basic research, with potential for translational application for this interaction, highlighting the versatile functionalization and application of TLT-1 as a contributor to clot formation, as a biomarker for disease progression and, extends to understand its regulation of fibrinogen deposition in pathophysiological models of disease.FibrinogenHemostasisPlateletsThromboinflammationThrombosisTrem Like Transcript-1