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Oakland University - News Archive - Professor studies human breath for disease indicators
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(Friday, January 30, 2004)Tj
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(Professor studies human breath for disease indicators)Tj
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(By )Tj
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(Jeff Samoray)Tj
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(, OU Web Writer)Tj
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(Oftentimes, when a patient is diagnosed with a deadly disease such as lu\
ng cancer or severe acute respiratory syndrome)Tj
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(\(SARS\), it is too late to provide an effective treatment. But research\
by Oakland University Associate Professor of Chemistry)Tj
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(John Seeley and his students is taking us one step closer toward the ear\
ly detection of these illnesses.)Tj
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(Seeley has teamed with researchers at Kettering University and McLaren R\
egional Medical Center in Flint to collect and)Tj
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(analyze human breath samples to see if certain chemical compounds identi\
fy conditions of disease. Seeley developed the)Tj
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(methodology and created the instrument that analyzes the compounds. His \
research has been funded by the Oakland)Tj
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(University Research Excellence Fund and the National Institute of Enviro\
nmental Health Sciences.)Tj
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(\223My background is more in atmospheric chemistry, but studying the com\
pounds in breath is similar to studying the compounds)Tj
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(in the atmosphere,\224 Seeley said. \223Prior to beginning my research, \
I attended a lecture in which a complicated technique for)Tj
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(analyzing human breath was discussed. I wanted to improve upon this appr\
oach and decided to pursue this research.\224)Tj
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(Seeley\222s wife Stacey, a chemistry professor at Kettering, received a \
grant from the McLaren Center to study breath samples)Tj
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(from osteoarthritis patients. Samples were collected from 40 participant\
s, who each released a deep breath in an airtight plastic)Tj
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(bag. Each sample then was run through a cartridge to collect concentrate\
d organic compounds. The cartridges then were sent)Tj
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(to OU for analysis.)Tj
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(\223The breath itself contains very little information as to the health \
of the individual,\224 Seeley said. \223The cartridges contain)Tj
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(thousands of organic compounds, which we need to quantify and isolate. O\
ur goal is to be able to take the reams of data we)Tj
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(collect and be able to pluck out the features that are the tell-tale sig\
ns of disease. My approach has been to develop a tool that)Tj
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(can do this.\224)Tj
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(In a lab in OU\222s Science and Engineering Building, master\222s studen\
t in chemistry Nicole Primeau sits in front of a computer)Tj
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(screen that displays small blotches and dots representing compounds from\
a breath sample. Eventually, Seeley\222s research may)Tj
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(lead to a simple, non-invasive means of detecting disease in humans, but\
it\222s likely that reaching such a method will take years)Tj
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(of research and further methodology refinement.)Tj
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(\223The level of complexity is quite high,\224 Primeau said. \223Advance\
s in computer science help, but the instrument we\222re using is)Tj
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(unable to handle the thousands of compounds that can be detected.\224)Tj
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(\223It\222s like looking into the night sky and asking how many stars yo\
u can see,\224 Seeley said. \223The answer is: it depends on how)Tj
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(deep you look.\224)Tj
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(Seeley, a 2003 OU Teaching Excellence Award winner, joined the OU facult\
y in 1997. He completed a Ph.D. in atmospheric)Tj
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(chemistry at the Massachusetts Institute of Technology in 1994 and serve\
d as a postdoctoral fellow at MIT until 1995, working in)Tj
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(the laboratory of Nobel Laureate in Chemistry Mario Molina. Seeley also \
served as a postdoctoral fellow at the Air Force)Tj
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(Research Laboratory from 1995 to 1997.)Tj
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(In his career at Oakland, Seeley has established an international reputa\
tion for research contributions that have helped improve)Tj
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(a fundamental aspect of separation science. He was invited to deliver th\
e keynote presentation at the International Symposium)Tj
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(on Comprehensive Two-Dimensional Chromotography in Volendam, the Netherl\
ands, in March 2003, demonstrating the impact)Tj
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(of his work on the field. Seeley\222s discoveries have been published in\
top-tier journals and are used in numerous environmental)Tj
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(and biomedical applications. The importance of his work is recognized wi\
th significant extramural research support from the)Tj
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(National Science Foundation and other major sponsors.)Tj
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(For more information on Seeley, his research interests and recent public\
ations, visit OU\222s )Tj
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(SUMMARY)Tj
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(Oftentimes, when a patient is diagnosed with a deadly disease such as lu\
ng cancer or severe acute respiratory syndrome \(SARS\), it is too late \
to)Tj
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(provide an effective treatment. But research by Oakland University Assoc\
iate Professor of Chemistry John Seeley and his students is taking us on\
e)Tj
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